Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care

Bruton’s tyrosine kinase (BTK) regulates critical signal transduction pathways involved in the pathobiology of rheumatoid arthritis (RA) and other autoimmune disorders. BMS-986142 is a potent and highly selective reversible small molecule inhibitor of BTK currently being investigated in clinical tri...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Gillooly, Kathleen M., Pulicicchio, Claudine, Pattoli, Mark A., Cheng, Lihong, Skala, Stacey, Heimrich, Elizabeth M., McIntyre, Kim W., Taylor, Tracy L., Kukral, Daniel W., Dudhgaonkar, Shailesh, Nagar, Jignesh, Banas, Dana, Watterson, Scott H., Tino, Joseph A., Fura, Aberra, Burke, James R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524405/
https://ncbi.nlm.nih.gov/pubmed/28742141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181782
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