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Superior Frontal Gyrus TOMM40-APOE Locus DNA Methylation in Alzheimer’s Disease

BACKGROUND: The APOE ɛ4 allele is the strongest known genetic risk factor for sporadic Alzheimer’s disease (AD). The neighboring TOMM40 gene has also been implicated in AD due to its close proximity to APOE. OBJECTIVE: Here we tested whether methylation of the TOMM40-APOE locus may influence ApoE pr...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis Rep
Main Authors: Bezuch, Natalia, Bradburn, Steven, Robinson, Andrew C., Pendleton, Neil, Payton, Antony, Murgatroyd, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150259/
https://ncbi.nlm.nih.gov/pubmed/34113784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/ADR-201000
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