Superior Frontal Gyrus TOMM40-APOE Locus DNA Methylation in Alzheimer’s Disease

BACKGROUND: The APOE ɛ4 allele is the strongest known genetic risk factor for sporadic Alzheimer’s disease (AD). The neighboring TOMM40 gene has also been implicated in AD due to its close proximity to APOE. OBJECTIVE: Here we tested whether methylation of the TOMM40-APOE locus may influence ApoE pr...

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Dettagli Bibliografici
Pubblicato in:J Alzheimers Dis Rep
Autori principali: Bezuch, Natalia, Bradburn, Steven, Robinson, Andrew C., Pendleton, Neil, Payton, Antony, Murgatroyd, Chris
Natura: Artigo
Lingua:Inglês
Pubblicazione: IOS Press 2021
Soggetti:
Research Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150259/
https://ncbi.nlm.nih.gov/pubmed/34113784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/ADR-201000
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