Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1

SIRT1 prevents retinal ganglion cell (RGC) loss in models of optic neuropathy following pharmacologic activation or genetic overexpression. The exact mechanism of loss is not known, prior evidence suggests this is through oxidative stress to either neighboring cells or RGC specifically. We investiga...

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Bibliografske podrobnosti
izdano v:Gene Ther
Main Authors: Ross, Ahmara G., McDougald, Devin S., Khan, Reas S., Duong, Thu T., Dine, Kimberly E., Aravand, Puya, Bennett, Jean, Chavali, Venkata Ramana Murthy, Shindler, Kenneth S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149296/
https://ncbi.nlm.nih.gov/pubmed/33589779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-021-00219-z
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