Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1

SIRT1 prevents retinal ganglion cell (RGC) loss in models of optic neuropathy following pharmacologic activation or genetic overexpression. The exact mechanism of loss is not known, prior evidence suggests this is through oxidative stress to either neighboring cells or RGC specifically. We investiga...

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Xehetasun bibliografikoak
Argitaratua izan da:Gene Ther
Egile Nagusiak: Ross, Ahmara G., McDougald, Devin S., Khan, Reas S., Duong, Thu T., Dine, Kimberly E., Aravand, Puya, Bennett, Jean, Chavali, Venkata Ramana Murthy, Shindler, Kenneth S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149296/
https://ncbi.nlm.nih.gov/pubmed/33589779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-021-00219-z
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