Dual SMAD inhibition and Wnt inhibition enable efficient and reproducible differentiations of induced pluripotent stem cells into retinal ganglion cells

Glaucoma is a group of progressive optic neuropathies that share common biological and clinical characteristics including irreversible changes to the optic nerve and visual field loss caused by the death of retinal ganglion cells (RGCs). The loss of RGCs manifests as characteristic cupping or optic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chavali, Venkata R. M., Haider, Naqi, Rathi, Sonika, Vrathasha, Vrathasha, Alapati, Teja, He, Jie, Gill, Kamaljot, Nikonov, Roman, Duong, Thu T., McDougald, Devin S., Nikonov, Sergei, O’Brien, Joan, Mills, Jason A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366935/
https://ncbi.nlm.nih.gov/pubmed/32678240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68811-8
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