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The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of p21, HDM2, BCL2 and MCL1 Genes in Chronic Lymphocytic Leukemia

Malignant cells in chronic lymphocytic leukemia (CLL) show resistance to apoptosis, as well as to chemotherapy, which are related to deletions or mutations of TP53, high expression of MCL1 and BCL2 genes and other abnormalities. Thus, the main goal of the present study was to assess the impact of ch...

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Bibliografski detalji
Izdano u:Cells
Glavni autori: Lipska, Katarzyna, Filip, Agata, Gumieniczek, Anna
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147495/
https://ncbi.nlm.nih.gov/pubmed/34063233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10051088
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