Dual dependence on BCL2 and MCL1 in T-cell prolymphocytic leukemia

Treatment of relapsed refractory T-PLL with venetoclax monotherapy results in only transient and minor clinical responses. In vitro analyses pre- and postvenetoclax indicate dual dependence on BCL2 and MCL1; combined BCL2 and MCL1 inhibition are synergistic.

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Smith, Victoria M., Lomas, Oliver, Constantine, Donna, Palmer, Lianne, Schuh, Anna H., Bruce, David, Gonchar, Oksana, Macip, Salvador, Jayne, Sandrine, Dyer, Martin J. S., Eyre, Toby A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Stimulus Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013268/
https://ncbi.nlm.nih.gov/pubmed/32040552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000917
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