Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells

Acute myeloid leukaemia (AML) cells often up-regulate pro-survival members of the BCL-2 protein family, such as BCL-2 and MCL-1, to avoid apoptosis. Venetoclax (ABT-199) targets BCL-2 and has shown promising efficacy in AML but over-expression of MCL-1 can cause resistance. A co-operative approach,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Grundy, Martin, Balakrishnan, Sahana, Fox, Matthew, Seedhouse, Claire H., Russell, Nigel H.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6340871/
https://ncbi.nlm.nih.gov/pubmed/30701031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26540
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