Tumor-targeted nanoparticles improve the therapeutic index of BCL2 and MCL1 dual inhibition

Cancer and normal cells use multiple antiapoptotic BCL2 proteins to prevent cell death. Therapeutic targeting of multiple BCL2 family proteins enhances tumor killing but is also associated with increased systemic toxicity. Here, we demonstrate that the dual targeting of MCL1 and BCL2 proteins using...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Bala Tannan, Neeta, Manzari, Mandana T., Herviou, Laurie, Da Silva Ferreira, Mariana, Hagen, Connor, Kiguchi, Hiroto, Manova-Todorova, Katia, Seshan, Venkatraman, de Stanchina, Elisa, Heller, Daniel A., Younes, Anas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8057264/
https://ncbi.nlm.nih.gov/pubmed/33067607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008017
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