Tumor-targeted nanoparticles improve the therapeutic index of BCL2 and MCL1 dual inhibition

Cancer and normal cells use multiple antiapoptotic BCL2 proteins to prevent cell death. Therapeutic targeting of multiple BCL2 family proteins enhances tumor killing but is also associated with increased systemic toxicity. Here, we demonstrate that the dual targeting of MCL1 and BCL2 proteins using...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Bala Tannan, Neeta, Manzari, Mandana T., Herviou, Laurie, Da Silva Ferreira, Mariana, Hagen, Connor, Kiguchi, Hiroto, Manova-Todorova, Katia, Seshan, Venkatraman, de Stanchina, Elisa, Heller, Daniel A., Younes, Anas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2021
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8057264/
https://ncbi.nlm.nih.gov/pubmed/33067607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008017
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