Poly(ADP-ribose) polymerase-1 gene in human tumor cell lines: Its expression and structural alteration

Poly(ADP-ribose) polymerase-1 (Parp-1) is involved in DNA repair and cell-death induction after DNA damage. Parp-1(−/−) mice show higher susceptibility to the carcinogenic effects of nitrosamine and azoxymethane. To elucidate the role of alterations of the PARP-1 gene in human carcinogenesis, we exa...

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Udgivet i:Proc Jpn Acad Ser B Phys Biol Sci
Main Authors: Masutani, Mitsuko, Nozaki, Tadashige, Sasaki, Hiroki, Yamada, Tesshi, Kohno, Takashi, Shimizu, Kimiko, Gotoh, Masahiro, Shiraishi, Masahiko, Yokota, Jun, Hirohashi, Setsuo, Nakagama, Hitoshi, Sugimura, Takashi
Format: Artigo
Sprog:Inglês
Udgivet: The Japan Academy 2004
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147301/
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