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Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition

To the best of our knowledge, bridgehead carbon benzofused-bridged ring systems have previously not been accessible to the synthetic community. Here, we describe a formal type-II [4 + 4] cycloaddition approach that provides fully sp(2)-carbon embedded anti-Bredt bicyclo[5.3.1] skeletons through the...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Jianyu, Wang, Xi, Xu, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8140143/
https://ncbi.nlm.nih.gov/pubmed/34021154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23344-0
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