Molecular conformations and dynamics of nucleotide repeats associated with neurodegenerative diseases: double helices and CAG hairpin loops

Pathogenic DNA secondary structures have been identified as a common and causative factor for expansion in trinucleotide, hexanucleotide, and other simple sequence repeats. These expansions underlie about fifty neurological and neuromuscular disorders known as “anticipation diseases”. Cell toxicity...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Comput Struct Biotechnol J
Главные авторы: Pan, Feng, Zhang, Yuan, Xu, Pengning, Man, Viet Hoang, Roland, Christopher, Weninger, Keith, Sagui, Celeste
Формат: Artigo
Язык:Inglês
Опубликовано: Research Network of Computational and Structural Biotechnology 2021
Предметы:
Review
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138726/
https://ncbi.nlm.nih.gov/pubmed/34093995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.04.037
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы