PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding

Tauopathies, such as Alzheimer's disease (AD), are neurodegenerative disorders characterized by the deposition of hyperphosphorylated tau aggregates. Proteopathic tau seeds spread through the brain in a temporospatial pattern, indicative of transsynaptic propagation. It is hypothesized that red...

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Vydáno v:J Biol Chem
Hlavní autoři: Soares, Alberto Carpinteiro, Ferreira, Andreia, Mariën, Jonas, Delay, Charlotte, Lee, Edward, Trojanowski, John Q., Moechars, Dieder, Annaert, Wim, De Muynck, Louis
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134070/
https://ncbi.nlm.nih.gov/pubmed/33831417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100636
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