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PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding
Tauopathies, such as Alzheimer's disease (AD), are neurodegenerative disorders characterized by the deposition of hyperphosphorylated tau aggregates. Proteopathic tau seeds spread through the brain in a temporospatial pattern, indicative of transsynaptic propagation. It is hypothesized that red...
Zapisane w:
| Wydane w: | J Biol Chem |
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| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8134070/ https://ncbi.nlm.nih.gov/pubmed/33831417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100636 |
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