PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding

Tauopathies, such as Alzheimer's disease (AD), are neurodegenerative disorders characterized by the deposition of hyperphosphorylated tau aggregates. Proteopathic tau seeds spread through the brain in a temporospatial pattern, indicative of transsynaptic propagation. It is hypothesized that red...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Soares, Alberto Carpinteiro, Ferreira, Andreia, Mariën, Jonas, Delay, Charlotte, Lee, Edward, Trojanowski, John Q., Moechars, Dieder, Annaert, Wim, De Muynck, Louis
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134070/
https://ncbi.nlm.nih.gov/pubmed/33831417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100636
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg