PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding

Tauopathies, such as Alzheimer's disease (AD), are neurodegenerative disorders characterized by the deposition of hyperphosphorylated tau aggregates. Proteopathic tau seeds spread through the brain in a temporospatial pattern, indicative of transsynaptic propagation. It is hypothesized that red...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Soares, Alberto Carpinteiro, Ferreira, Andreia, Mariën, Jonas, Delay, Charlotte, Lee, Edward, Trojanowski, John Q., Moechars, Dieder, Annaert, Wim, De Muynck, Louis
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134070/
https://ncbi.nlm.nih.gov/pubmed/33831417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100636
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