Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies

Antibodies that target the glycan cap epitope on the ebolavirus glycoprotein (GP) are common in the adaptive response of survivors. A subset is known to be broadly neutralizing, but the details of their epitopes and basis for neutralization are not well understood. Here, we present cryoelectron micr...

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Udgivet i:Cell Rep
Main Authors: Murin, Charles D., Gilchuk, Pavlo, Ilinykh, Philipp A., Huang, Kai, Kuzmina, Natalia, Shen, Xiaoli, Bruhn, Jessica F., Bryan, Aubrey L., Davidson, Edgar, Doranz, Benjamin J., Williamson, Lauren E., Copps, Jeffrey, Alkutkar, Tanwee, Flyak, Andrew I., Bukreyev, Alexander, Crowe, James E., Ward, Andrew B.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133395/
https://ncbi.nlm.nih.gov/pubmed/33852862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108984
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