Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

Structural principles underlying the composition of protective antiviral monoclonal antibody (mAb) cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic mAb cocktail against Ebola virus. We systematically analyzed the antibody repertoire in human survivors...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Gilchuk, Pavlo, Murin, Charles D., Milligan, Jacob C., Cross, Robert W., Mire, Chad E., Ilinykh, Philipp A., Huang, Kai, Kuzmina, Natalia, Altman, Pilar X., Hui, Sean, Gunn, Bronwyn M., Bryan, Aubrey L., Davidson, Edgar, Doranz, Benjamin J., Turner, Hannah L., Alkutkar, Tanwee, Flinko, Robin, Orlandi, Chiara, Carnahan, Robert, Nargi, Rachel, Bombardi, Robin G., Vodzak, Megan E., Li, Sheng, Okoli, Adaora, Ibeawuchi, Morris, Ohiaeri, Benjamin, Lewis, George K., Alter, Galit, Bukreyev, Alexander, Saphire, Erica Ollmann, Geisbert, Thomas W., Ward, Andrew B., Crowe, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111202/
https://ncbi.nlm.nih.gov/pubmed/32023489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.01.001
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