Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

Structural principles underlying the composition of protective antiviral monoclonal antibody (mAb) cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic mAb cocktail against Ebola virus. We systematically analyzed the antibody repertoire in human survivors...

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書誌詳細
出版年:Immunity
主要な著者: Gilchuk, Pavlo, Murin, Charles D., Milligan, Jacob C., Cross, Robert W., Mire, Chad E., Ilinykh, Philipp A., Huang, Kai, Kuzmina, Natalia, Altman, Pilar X., Hui, Sean, Gunn, Bronwyn M., Bryan, Aubrey L., Davidson, Edgar, Doranz, Benjamin J., Turner, Hannah L., Alkutkar, Tanwee, Flinko, Robin, Orlandi, Chiara, Carnahan, Robert, Nargi, Rachel, Bombardi, Robin G., Vodzak, Megan E., Li, Sheng, Okoli, Adaora, Ibeawuchi, Morris, Ohiaeri, Benjamin, Lewis, George K., Alter, Galit, Bukreyev, Alexander, Saphire, Erica Ollmann, Geisbert, Thomas W., Ward, Andrew B., Crowe, James E.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier Inc. 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111202/
https://ncbi.nlm.nih.gov/pubmed/32023489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.01.001
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