Peripherally delivered hepatopreferential insulin analog insulin-406 mimics the hypoglycaemia-sparing effect of portal vein human insulin infusion in dogs

AIMS: We previously quantified the hypoglycaemia-sparing effect of portal vs peripheral human insulin delivery. The current investigation aimed to determine whether a bioequivalent peripheral vein infusion of a hepatopreferential insulin analog, insulin-406, could similarly protect against hypoglyca...

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Bibliografske podrobnosti
izdano v:Diabetes Obes Metab
Main Authors: Gregory, Justin M., Kraft, Guillaume, Scott, Melanie F., Neal, Doss W., Farmer, Ben, Smith, Marta S., Hastings, Jon R., Madsen, Peter, Kjeldsen, Thomas B., Hostrup, Susanne, Brand, Christian L., Fledelius, Christian, Nishimura, Erica, Cherrington, Alan D.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132115/
https://ncbi.nlm.nih.gov/pubmed/31183936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.13808
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