Peripherally delivered hepatopreferential insulin analog insulin-406 mimics the hypoglycaemia-sparing effect of portal vein human insulin infusion in dogs

AIMS: We previously quantified the hypoglycaemia-sparing effect of portal vs peripheral human insulin delivery. The current investigation aimed to determine whether a bioequivalent peripheral vein infusion of a hepatopreferential insulin analog, insulin-406, could similarly protect against hypoglyca...

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Detalhes bibliográficos
Publicado no:Diabetes Obes Metab
Main Authors: Gregory, Justin M., Kraft, Guillaume, Scott, Melanie F., Neal, Doss W., Farmer, Ben, Smith, Marta S., Hastings, Jon R., Madsen, Peter, Kjeldsen, Thomas B., Hostrup, Susanne, Brand, Christian L., Fledelius, Christian, Nishimura, Erica, Cherrington, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132115/
https://ncbi.nlm.nih.gov/pubmed/31183936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.13808
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