Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes

Hypoglycemia limits optimal glycemic control in type 1 diabetes mellitus (T1DM), making novel strategies to mitigate it desirable. We hypothesized that portal (Po) vein insulin delivery would lessen hypoglycemia. In the conscious dog, insulin was infused into the hepatic Po vein or a peripheral (Pe)...

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Dades bibliogràfiques
Publicat a:Diabetes
Autors principals: Gregory, Justin M., Kraft, Guillaume, Scott, Melanie F., Neal, Doss W., Farmer, Ben, Smith, Marta S., Hastings, Jon R., Allen, Eric J., Donahue, E. Patrick, Rivera, Noelia, Winnick, Jason J., Edgerton, Dale S., Nishimura, Erica, Fledelius, Christian, Brand, Christian L., Cherrington, Alan D.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2015
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587648/
https://ncbi.nlm.nih.gov/pubmed/26085570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0071
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