Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes

Hypoglycemia limits optimal glycemic control in type 1 diabetes mellitus (T1DM), making novel strategies to mitigate it desirable. We hypothesized that portal (Po) vein insulin delivery would lessen hypoglycemia. In the conscious dog, insulin was infused into the hepatic Po vein or a peripheral (Pe)...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Gregory, Justin M., Kraft, Guillaume, Scott, Melanie F., Neal, Doss W., Farmer, Ben, Smith, Marta S., Hastings, Jon R., Allen, Eric J., Donahue, E. Patrick, Rivera, Noelia, Winnick, Jason J., Edgerton, Dale S., Nishimura, Erica, Fledelius, Christian, Brand, Christian L., Cherrington, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587648/
https://ncbi.nlm.nih.gov/pubmed/26085570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0071
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