APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function

The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer Disease (AD) and greatly influences the development of amyloid-β (Aβ) pathology. Our current study investigated the potential therapeutic effects of the anti-human APOE antibody HAE-4, whi...

Full description

Saved in:
Bibliographic Details
Published in:Sci Transl Med
Main Authors: Xiong, Monica, Jiang, Hong, Serrano, Javier Remolina, Gonzales, Ernesto R., Wang, Chao, Gratuze, Maud, Hoyle, Rosa, Bien-Ly, Nga, Silverman, Adam P., Sullivan, Patrick M., Watts, Ryan J., Ulrich, Jason D., Zipfel, Gregory J., Holtzman, David M.
Format: Artigo
Language:Inglês
Published: 2021
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8128342/
https://ncbi.nlm.nih.gov/pubmed/33597265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abd7522
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items