APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function

The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer Disease (AD) and greatly influences the development of amyloid-β (Aβ) pathology. Our current study investigated the potential therapeutic effects of the anti-human APOE antibody HAE-4, whi...

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Vydáno v:Sci Transl Med
Hlavní autoři: Xiong, Monica, Jiang, Hong, Serrano, Javier Remolina, Gonzales, Ernesto R., Wang, Chao, Gratuze, Maud, Hoyle, Rosa, Bien-Ly, Nga, Silverman, Adam P., Sullivan, Patrick M., Watts, Ryan J., Ulrich, Jason D., Zipfel, Gregory J., Holtzman, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8128342/
https://ncbi.nlm.nih.gov/pubmed/33597265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abd7522
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