Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

The apolipoprotein E E4 allele of the APOE gene is the strongest genetic factor for late-onset Alzheimer disease (LOAD). There is compelling evidence that apoE influences Alzheimer disease (AD) in large part by affecting amyloid β (Aβ) aggregation and clearance; however, the molecular mechanism unde...

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Udgivet i:J Clin Invest
Main Authors: Liao, Fan, Li, Aimin, Xiong, Monica, Bien-Ly, Nga, Jiang, Hong, Zhang, Yin, Finn, Mary Beth, Hoyle, Rosa, Keyser, Jennifer, Lefton, Katheryn B., Robinson, Grace O., Serrano, Javier Remolina, Silverman, Adam P., Guo, Jing L., Getz, Jennifer, Henne, Kirk, Leyns, Cheryl E.G., Gallardo, Gilbert, Ulrich, Jason D., Sullivan, Patrick M., Lerner, Eli Paul, Hudry, Eloise, Sweeney, Zachary K., Dennis, Mark S., Hyman, Bradley T., Watts, Ryan J., Holtzman, David M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919821/
https://ncbi.nlm.nih.gov/pubmed/29600961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96429
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