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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation
The apolipoprotein E E4 allele of the APOE gene is the strongest genetic factor for late-onset Alzheimer disease (LOAD). There is compelling evidence that apoE influences Alzheimer disease (AD) in large part by affecting amyloid β (Aβ) aggregation and clearance; however, the molecular mechanism unde...
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Publicado no: | J Clin Invest |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Clinical Investigation
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5919821/ https://ncbi.nlm.nih.gov/pubmed/29600961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96429 |
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