Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

The apolipoprotein E E4 allele of the APOE gene is the strongest genetic factor for late-onset Alzheimer disease (LOAD). There is compelling evidence that apoE influences Alzheimer disease (AD) in large part by affecting amyloid β (Aβ) aggregation and clearance; however, the molecular mechanism unde...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Liao, Fan, Li, Aimin, Xiong, Monica, Bien-Ly, Nga, Jiang, Hong, Zhang, Yin, Finn, Mary Beth, Hoyle, Rosa, Keyser, Jennifer, Lefton, Katheryn B., Robinson, Grace O., Serrano, Javier Remolina, Silverman, Adam P., Guo, Jing L., Getz, Jennifer, Henne, Kirk, Leyns, Cheryl E.G., Gallardo, Gilbert, Ulrich, Jason D., Sullivan, Patrick M., Lerner, Eli Paul, Hudry, Eloise, Sweeney, Zachary K., Dennis, Mark S., Hyman, Bradley T., Watts, Ryan J., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919821/
https://ncbi.nlm.nih.gov/pubmed/29600961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96429
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