Loss of Neprilysin Function Promotes Amyloid Plaque Formation and Causes Cerebral Amyloid Angiopathy

Cerebral deposition of the amyloid β protein (Aβ), an invariant feature of Alzheimer’s disease, reflects an imbalance between the rates of Aβ production and clearance. The causes of Aβ elevation in the common late-onset form of Alzheimer’s disease (LOAD) are largely unknown. There is evidence that t...

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Detalhes bibliográficos
Main Authors: Farris, Wesley, Schütz, Sonja G., Cirrito, John R., Shankar, Ganesh M., Sun, Xiaoyan, George, Ana, Leissring, Malcolm A., Walsh, Dominic M., Qiu, Wei Qiao, Holtzman, David M., Selkoe, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941603/
https://ncbi.nlm.nih.gov/pubmed/17591969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070105
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