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Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors
Mutations in the isocitrate dehydrogenase-1 and -2 (IDH1/2) genes were first identified in glioma and acute myeloid leukemia (AML), and subsequently found in multiple other tumor types. These neomorphic mutations convert the normal product of enzyme, α-ketoglutarate (αKG), to the oncometabolite 2-hy...
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| Publicado no: | NAR Cancer |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8127964/ https://ncbi.nlm.nih.gov/pubmed/34027408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcab018 |
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