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Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
Alpha Thalassemia/Mental Retardation Syndrome X-Linked (ATRX) is mutated frequently in gliomas and represents a potential target for cancer therapies. ATRX is known to function as a histone chaperone that helps incorporate histone variant, H3.3, into the genome. Studies have implicated ATRX in key D...
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| 出版年: | Transl Oncol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Neoplasia Press
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8203843/ https://ncbi.nlm.nih.gov/pubmed/34118569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101147 |
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