Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity

Alpha Thalassemia/Mental Retardation Syndrome X-Linked (ATRX) is mutated frequently in gliomas and represents a potential target for cancer therapies. ATRX is known to function as a histone chaperone that helps incorporate histone variant, H3.3, into the genome. Studies have implicated ATRX in key D...

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Detalles Bibliográficos
Publicado en:Transl Oncol
Main Authors: Garbarino, Jennifer, Eckroate, Jillian, Sundaram, Ranjini K., Jensen, Ryan B., Bindra, Ranjit S.
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press 2021
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203843/
https://ncbi.nlm.nih.gov/pubmed/34118569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101147
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