A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis

OBJECTIVE: p21 (Cdc42/Rac1) activated Kinase 1 (PAK1) is a candidate susceptibility factor for type 2 diabetes (T2D). PAK1 is depleted in the islets from T2D donors, compared to control individuals. In addition, whole-body PAK1 knock out (PAK1-KO) in mice worsens the T2D-like effects of high-fat die...

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Udgivet i:Metabolism
Main Authors: Ahn, Miwon, Oh, Eunjin, McCown, Erika M., Wang, Xin, Veluthakal, Rajakrishnan, Thurmond, Debbie C.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8123936/
https://ncbi.nlm.nih.gov/pubmed/33181191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2020.154431
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