DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle

AIMS/HYPOTHESIS: Skeletal muscle accounts for >80% of insulin-stimulated glucose uptake; dysfunction of this process underlies insulin resistance and type 2 diabetes. Insulin sensitivity is impaired in mice deficient in the double C2 domain β (DOC2B) protein, while whole-body overexpression of DO...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Diabetologia
Auteurs principaux: Zhang, Jing, Oh, Eunjin, Merz, Karla E., Aslamy, Arianne, Veluthakal, Rajakrishnan, Salunkhe, Vishal A., Ahn, Miwon, Tunduguru, Ragadeepthi, Thurmond, Debbie C.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451670/
https://ncbi.nlm.nih.gov/pubmed/30707251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-019-4824-2
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires