DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle

AIMS/HYPOTHESIS: Skeletal muscle accounts for >80% of insulin-stimulated glucose uptake; dysfunction of this process underlies insulin resistance and type 2 diabetes. Insulin sensitivity is impaired in mice deficient in the double C2 domain β (DOC2B) protein, while whole-body overexpression of DO...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Zhang, Jing, Oh, Eunjin, Merz, Karla E., Aslamy, Arianne, Veluthakal, Rajakrishnan, Salunkhe, Vishal A., Ahn, Miwon, Tunduguru, Ragadeepthi, Thurmond, Debbie C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451670/
https://ncbi.nlm.nih.gov/pubmed/30707251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-019-4824-2
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