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The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets
AIMS/HYPOTHESIS: Human islets from type 2 diabetic donors are reportedly 80% deficient in the p21 (Cdc42/Rac)-activated kinase, PAK1. PAK1 is implicated in beta cell function and maintenance of beta cell mass. We questioned the mechanism(s) by which PAK1 deficiency potentially contributes to increas...
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| Pubblicato in: | Diabetologia |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5266538/ https://ncbi.nlm.nih.gov/pubmed/27394663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-4042-0 |
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