The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets

AIMS/HYPOTHESIS: Human islets from type 2 diabetic donors are reportedly 80% deficient in the p21 (Cdc42/Rac)-activated kinase, PAK1. PAK1 is implicated in beta cell function and maintenance of beta cell mass. We questioned the mechanism(s) by which PAK1 deficiency potentially contributes to increas...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Ahn, Miwon, Yoder, Stephanie M., Wang, Zhanxiang, Oh, Eunjin, Ramalingam, Latha, Tunduguru, Ragadeepthi, Thurmond, Debbie C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266538/
https://ncbi.nlm.nih.gov/pubmed/27394663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-4042-0
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