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Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells

Skeletal muscle accounts for ~80% of postprandial glucose clearance, and skeletal muscle glucose clearance is crucial for maintaining insulin sensitivity and euglycemia. Insulin-stimulated glucose clearance/uptake entails recruitment of glucose transporter 4 (GLUT4) to the plasma membrane (PM) in a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem Pharmacol
Prif Awduron: Tunduguru, Ragadeepthi, Chiu, Tim T., Ramalingam, Latha, Elmendorf, Jeffrey S., Klip, Amira, Thurmond, Debbie C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418524/
https://ncbi.nlm.nih.gov/pubmed/25199455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.08.033
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