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The cGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease

The presence of DNA in the cytosol is usually a sign of microbial infections, which alerts the host innate immune system to mount a defense response. Cyclic GMP-AMP synthase (cGAS) is a critical cytosolic DNA sensor that elicits robust innate immune responses through the production of the second mes...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Ma, Ruihua, Ortiz Serrano, Tatiana P., Davis, Jennifer, Prigge, Andrew D., Ridge, Karen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121456/
https://ncbi.nlm.nih.gov/pubmed/32860267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202001607R
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