Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis

The identification and development of new anti-tubercular agents are a priority research area. We identified the trifluoromethyl pyrimidinone series of compounds in a whole-cell screen against Mycobacterium tuberculosis. Fifteen primary hits had minimum inhibitory concentrations (MICs) with good pot...

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Опубликовано в: :Front Chem
Главные авторы: Hembre, Erik, Early, Julie V., Odingo, Joshua, Shelton, Catherine, Anoshchenko, Olena, Guzman, Junitta, Flint, Lindsay, Dennison, Devon, McNeil, Matthew B., Korkegian, Aaron, Ovechkina, Yulia, Ornstein, Paul, Masquelin, Thierry, Hipskind, Philip A., Parish, Tanya
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2021
Предметы:
Chemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8117417/
https://ncbi.nlm.nih.gov/pubmed/33996738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2021.613349
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