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Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential

A family of compounds typified by an anthranilic amide 1 was identified from a whole-cell screening effort targeted at identifying compounds that disrupt pH homeostasis in Mycobacterium tuberculosis. 1 demonstrated bactericidal activity against non-replicating M. tuberculosis in pH 4.5 buffer (MBC(4...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Smith, Jake, Wescott, Heather, Early, Julie, Mullen, Steven, Guzman, Junitta, Odingo, Joshua, Lamar, Jason, Parish, Tanya
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596218/
https://ncbi.nlm.nih.gov/pubmed/31303991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00088g
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