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Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis
[Image: see text] To find new inhibitors of Mycobacterium tuberculosis that have novel mechanisms of action, we miniaturized a high throughput screen to identify compounds that disrupt pH homeostasis. We adapted and validated a 384-well format assay to determine intrabacterial pH using a ratiometric...
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| 出版年: | ACS Infect Dis |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2018
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6371205/ https://ncbi.nlm.nih.gov/pubmed/30501173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00256 |
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