Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis

[Image: see text] To find new inhibitors of Mycobacterium tuberculosis that have novel mechanisms of action, we miniaturized a high throughput screen to identify compounds that disrupt pH homeostasis. We adapted and validated a 384-well format assay to determine intrabacterial pH using a ratiometric...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Early, Julie, Ollinger, Juliane, Darby, Crystal, Alling, Torey, Mullen, Steven, Casey, Allen, Gold, Ben, Ochoada, Jason, Wiernicki, Todd, Masquelin, Thierry, Nathan, Carl, Hipskind, Philip A., Parish, Tanya
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6371205/
https://ncbi.nlm.nih.gov/pubmed/30501173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00256
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