The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents

We identified a di-substituted triazolopyrimidine with anti-tubercular activity against Mycobacterium tuberculosis. Three segments of the scaffold were examined rationally to establish a structure-activity relationship with the goal of improving potency and maintaining good physicochemical propertie...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Zuniga, Edison S., Korkegian, Aaron, Mullen, Steven, Hembre, Erik J., Ornstein, Paul L., Cortez, Guillermo, Biswas, Kallolmay, Kumar, Naresh, Cramer, Jeffrey, Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Parish, Tanya
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513444/
https://ncbi.nlm.nih.gov/pubmed/28576632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.05.030
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