Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA

Isoniazid inhibits Mycobacterium tuberculosis InhA and is a key component of drug regimens that treat tuberculosis. However, the high rate of resistance against isoniazid is a contributing factor to the emergence of multi-drug resistance strains of M. tuberculosis. The 4-hydroxy-2-pyridine NITD-916...

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I publikationen:Tuberculosis (Edinb)
Huvudupphovsmän: McNeil, Matthew B, Dennison, Devon, Shelton, Catherine, Flint, Lindsay, Korkegian, Aaron, Parish, Tanya
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679704/
https://ncbi.nlm.nih.gov/pubmed/29050761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2017.09.003
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