Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model

AN12855 is a direct, cofactor-independent inhibitor of InhA in Mycobacterium tuberculosis. In the C3HeB/FeJ mouse model with caseous necrotic lung lesions, AN12855 proved efficacious with a significantly lower resistance frequency than isoniazid. AN12855 drug levels were better retained in necrotic...

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Opis bibliograficzny
Wydane w:Antimicrob Agents Chemother
Główni autorzy: Robertson, Gregory T., Ektnitphong, Victoria A., Scherman, Michael S., McNeil, Matthew B., Dennison, Devon, Korkegian, Aaron, Smith, Anthony J., Halladay, Jason, Carter, David S., Xia, Yi, Zhou, Yasheen, Choi, Wai, Berry, Pamela W., Mao, Weimin, Hernandez, Vincent, Alley, M. R. K., Parish, Tanya, Lenaerts, Anne J.
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology 2019
Hasła przedmiotowe:
Experimental Therapeutics
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496157/
https://ncbi.nlm.nih.gov/pubmed/30745397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02071-18
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