Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model

AN12855 is a direct, cofactor-independent inhibitor of InhA in Mycobacterium tuberculosis. In the C3HeB/FeJ mouse model with caseous necrotic lung lesions, AN12855 proved efficacious with a significantly lower resistance frequency than isoniazid. AN12855 drug levels were better retained in necrotic...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Robertson, Gregory T., Ektnitphong, Victoria A., Scherman, Michael S., McNeil, Matthew B., Dennison, Devon, Korkegian, Aaron, Smith, Anthony J., Halladay, Jason, Carter, David S., Xia, Yi, Zhou, Yasheen, Choi, Wai, Berry, Pamela W., Mao, Weimin, Hernandez, Vincent, Alley, M. R. K., Parish, Tanya, Lenaerts, Anne J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2019
Ämnen:
Experimental Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496157/
https://ncbi.nlm.nih.gov/pubmed/30745397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02071-18
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