Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome

Inflammasomes are filamentous signaling platforms integral to innate immunity. Currently, little is known about how these structurally similar filaments recognize and distinguish one another. A cryo-EM structure of the AIM2(PYD) filament reveals that the architecture of the upstream filament is esse...

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Publicat a:Nat Commun
Autors principals: Matyszewski, Mariusz, Zheng, Weili, Lueck, Jacob, Mazanek, Zachary, Mohideen, Naveen, Lau, Albert Y., Egelman, Edward H., Sohn, Jungsan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115694/
https://ncbi.nlm.nih.gov/pubmed/33980849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23045-8
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