Cryo-EM structure of the NLRC4(CARD) filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly

Inflammasomes are supramolecular signaling platforms integral to innate immune defense against invading pathogens. The NOD-like receptor (NLR) family apoptosis inhibitory protein (NAIP)·NLR family caspase-recruiting domain (CARD) domain-containing 4 (NLRC4) inflammasome recognizes intracellular bact...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Matyszewski, Mariusz, Zheng, Weili, Lueck, Jacob, Antiochos, Brendan, Egelman, Edward H., Sohn, Jungsan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311515/
https://ncbi.nlm.nih.gov/pubmed/30385506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006050
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