Cryo-EM structure of the NLRC4(CARD) filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly

Inflammasomes are supramolecular signaling platforms integral to innate immune defense against invading pathogens. The NOD-like receptor (NLR) family apoptosis inhibitory protein (NAIP)·NLR family caspase-recruiting domain (CARD) domain-containing 4 (NLRC4) inflammasome recognizes intracellular bact...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Matyszewski, Mariusz, Zheng, Weili, Lueck, Jacob, Antiochos, Brendan, Egelman, Edward H., Sohn, Jungsan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311515/
https://ncbi.nlm.nih.gov/pubmed/30385506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006050
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