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Digital signaling network drives the assembly of the AIM2-ASC inflammasome

The AIM2-ASC inflammasome is a filamentous signaling platform essential for mounting host defense against cytoplasmic dsDNA arising not only from invading pathogens but also from damaged organelles. Currently, the design principles of its underlying signaling network remain poorly understood at the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Matyszewski, Mariusz, Morrone, Seamus R., Sohn, Jungsan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834677/
https://ncbi.nlm.nih.gov/pubmed/29440442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712860115
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