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IFI16 filament formation in salivary epithelial cells shapes the anti-IFI16 immune response in Sjögren’s syndrome
IFN-inducible protein 16 (IFI16) is an innate immune sensor that forms filamentous oligomers when activated by double-stranded DNA (dsDNA). Anti-IFI16 autoantibodies occur in patients with Sjögren’s syndrome (SS) and associate with severe phenotypic features. We undertook this study to determine whe...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6237237/ https://ncbi.nlm.nih.gov/pubmed/30232276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120179 |
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