IFI16 filament formation in salivary epithelial cells shapes the anti-IFI16 immune response in Sjögren’s syndrome

IFN-inducible protein 16 (IFI16) is an innate immune sensor that forms filamentous oligomers when activated by double-stranded DNA (dsDNA). Anti-IFI16 autoantibodies occur in patients with Sjögren’s syndrome (SS) and associate with severe phenotypic features. We undertook this study to determine whe...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Antiochos, Brendan, Matyszewski, Mariusz, Sohn, Jungsan, Casciola-Rosen, Livia, Rosen, Antony
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237237/
https://ncbi.nlm.nih.gov/pubmed/30232276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120179
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