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A metallo-β-lactamase enzyme for internal detoxification of the antibiotic thienamycin
Thienamycin, the first representative of carbapenem antibiotics was discovered in the mid-1970s from soil microorganism, Streptomyces cattleya, during the race to discover inhibitors of bacterial peptidoglycan synthesis. Chemically modified into imipenem (N-formimidoyl thienamycin), now one of the m...
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| Udgivet i: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8115136/ https://ncbi.nlm.nih.gov/pubmed/33980996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89600-x |
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