A metallo-β-lactamase enzyme for internal detoxification of the antibiotic thienamycin

Thienamycin, the first representative of carbapenem antibiotics was discovered in the mid-1970s from soil microorganism, Streptomyces cattleya, during the race to discover inhibitors of bacterial peptidoglycan synthesis. Chemically modified into imipenem (N-formimidoyl thienamycin), now one of the m...

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Publicado no:Sci Rep
Main Authors: Diene, Seydina M., Pinault, Lucile, Baron, Sophie Alexandra, Azza, Saïd, Armstrong, Nicholas, Hadjadj, Linda, Chabrière, Eric, Rolain, Jean-Marc, Pontarotti, Pierre, Raoult, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115136/
https://ncbi.nlm.nih.gov/pubmed/33980996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89600-x
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