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α-Methylene-β-Lactone Scaffold for Developing Chemical Probes at the Two Ends of the Selectivity Spectrum
The utilities of an α-methylene-β-lactone (MeLac) moiety as a warhead composed of multiple electrophilic sites are reported. We demonstrate that a MeLac-alkyne not only reacts with diverse proteins as a broadly reactive measurement probe but also recruits reduced endogenous glutathione (GSH) to asse...
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| Publicado en: | Chembiochem |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8114233/ https://ncbi.nlm.nih.gov/pubmed/32964640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000605 |
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