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Immunomodulation and the quorum sensing molecule 3-oxo-C(12)-homoserine lactone: The importance of chemical scaffolding for probe development()
As a guide for chemical probe design, focused analogue synthetic studies were undertaken upon the lactone ring of 3-oxo-C(12)-homoserine lactone. We have concluded that hydrolytic instability of the heterocyclic ring is pivotal for its ability to modulate immune signaling and probe preparation was a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3566768/ https://ncbi.nlm.nih.gov/pubmed/23328974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc38851d |
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