Synthesis of “clickable” acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation

Alkynyl- and azido-tagged 3-oxo-C(12)-acylhomoserine lactone probes have been synthesized to examine their potential utility as probes for discovering the mammalian protein target of the Pseudomonas aeruginosa autoinducer, 3-oxo-C(12)-acylhomoserine lactone. Although such substitutions are commonly...

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Detalhes bibliográficos
Main Authors: Garner, Amanda L., Yu, Jing, Struss, Anjali Kumari, Lowery, Colin A., Zhu, Jie, Kim, Sook Kyung, Park, Junguk, Mayorov, Alexander V., Kaufmann, Gunnar F., Kravchenko, Vladimir V., Janda, Kim D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081916/
https://ncbi.nlm.nih.gov/pubmed/21190852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.11.122
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